产品货号：
Z12809
中文名称：
CDK5抗体
英文名称：
Anti-CDK5 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CDK5 Antibody (C-term) |
| 指标别名 | CDK5;Cell division protein kinase 5;cyclin dependent kinase 5;PSSALRE;TPKII catalytic subunit |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | IF,FCM,WB |
| 基因名称 | CDK5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This CDK5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 254-289 amino acids from the C-terminal region of human CDK5. |
| 计算分子量 | 33kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry.Interacts with D1 and D3- type G1 cyclins.Phosphorylates SRC,NOS3,VIM/vimentin,p35/CDK5R1,MEF2A,SIPA1L1,SH3GLB1,PXN,PAK1,MCAM/MUC18,SEPT5,SYN1,DNM1,AMPH,SYNJ1,CDK16,RAC1,RHOA,CDC42,TONEBP/NFAT5,MAPT/TAU,MAP1B,histone H1,p53/TP53,HDAC1,APEX1,PTK2/FAK1,huntingtin/HTT,ATM,MAP2,NEFH and NEFM.Regulates several neuronal development and physiological processes including neuronal survival,migration and differentiation,axonal and neurite growth,synaptogenesis,oligodendrocyte differentiation,synaptic plasticity and neurotransmission,by phosphorylating key proteins.Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39),especially in post-mitotic neurons,and promotes CDK5R1 (p35) expression in an autostimulation loop.Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g.PAK1,RAC1,RHOA,CDC42) or microtubule-binding proteins (e.g.MAPT/TAU,MAP2,MAP1B),and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis.Phosphorylates also exocytosis associated proteins such as MCAM/MUC18,SEPT5,SYN1,and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1,AMPH and SYNJ1 at synaptic terminals.In the mature central nervous system (CNS),regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity;synaptic vesicle exocytosis,vesicles fusion with the presynaptic membrane,and endocytosis.Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3,and negatively regulating of JNK3/MAPK10 activity.Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation,and induces transactivation of p53/TP53 target genes,thus regulating apoptosis.Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation.During aberrant cell-cycle activity and DNA damage,p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1.DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation.Negative regulator of Wnt/beta-catenin signaling pathway.Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway,which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells;phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner,the initial event in assembly of the GAIT complex.Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons.Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization.MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin,thus leading to neuronal apoptosis.APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation,resulting in accumulation of DNA damage and contributing to neuronal death.NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels.SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization.May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation.Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling. |
| Uniprot ID | Q00535 |
相关搜索：CDK5抗体，CDK5(C-term)多抗，Anti-CDK5 Antibody (C-term)